Searching for Molecular Solutions:Empirical Discovery and Its Future Ian S. Dunn
Consumed by her pursuit of a Theory of Everything, a brilliant California scientist struggles to deal with life in and outside the lab Doctor Esme Charbonneau Tallich´s passion is cosmology, the science of the origin of the universe; specifically, she is searching for a TOE, or a Theory of Everything. Esme is a feminist maverick, a rogue thinker. Hired as a professor of molecular biology at the University of Greater California, she prefers the ´´bench science´´ of organic chemistry at one extreme and ´´walking out into space´´ at the other. Her marriage to a TV director and aspiring stand-up comedian is rocky. Esme´s five-year-old daughter, Ollie, the sun in her galaxy, seems an enigma. Too readily diagnosed by professionals as ´´challenged´´, even possibly autistic, she is, like Esme, a renegade thinker and creative mind. Her use of language is poetic, not deficit driven or conventional. As her marriage dissolves, Esme´s struggle to maintain custody of Ollie and autonomy for herself and her work is set against the backdrop of the beckoning cosmos. Her tantalizing closeness to discovery of a grand unified theory - as psychiatric professionals, lawyers, and Esme´s estranged husband also close in on Ollie, seeking to medicate and restructure her - heightens tension while also offering hope. The discovery that Esme seeks is twofold: enlightenment and equilibrium in the troubled universes of her personal and professional lives. Saving St. Germ is a provocative, dramatic look at a single mother´s life at the edge of the universe - and the center of the human heart. 1. Language: English. Narrator: Jennifer Woodward. Audio sample: http://samples.audible.de/bk/adbl/017596de/bk_rhde_002536_sample.mp3. Digital audiobook in aax.
This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinsons disease, Alzheimers disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research. Amy K. Reeve Amy did her undergraduate degree in Neuroscience at Edinburgh University before moving to the Mitochondrial Research Group at Newcastle University for her PhD studies. She completed her PhD in the study of the molecular mechanisms of neurodegenerative disease in 2007 and now has her own research group within the Wellcome Trust Centre for Mitochondrial Research. Her current research interests centre around understanding the mechanisms behind the neurodegeneration seen in Parkinsons disease, and the contribution of mitochondrial dysfunction to these changes. Funded by Parkinsons UK as a research fellow Amys interests lie in understanding how changes within mitochondria, mitochondrial transport and the interaction of mitochondrial with alpha-synuclein contributes to the development of Parkinsons disease. Eve M. Simcox Eve did her undergraduate degree in Biomedical Science at Newcastle University and continued her studies within the Mitochondrial Research Group for her PhD. She completed her PhD in the study of the turnover and dynamics of mitochondria in neurodegenerative disease in 2014 and now works as the impact officer for the faculty of Science, Agriculture and Engineering. Michael R. Duchen Michael obtained his Bachelor of Medicine degree from Oxford and London Universities, and moved to UCL for his PhD studies. He has remained at UCL since, where he is now a Professor of Physiology. Michael founded and leads the UCL consortium for Mitochondrial Research and leads a successful research group. Michaels interests lie primarily in understanding the relationships between mitochondrial biology and cell signalling. His research groups main interest lies in understanding the inter-relationship between calcium signalling, mitochondria and free radical biology in cell physiology and pathophysiology. Particular contributions have been made into understanding the contribution of mitochondrial dysfunction to cell injury and death. Doug M. Turnbull Professor Turnbull is a clinical academic who leads a basic science research programme in conjunction with developing clinical services. He has three main roles. Director of the Wellcome Trust Centre for Mitochondrial Research. The Wellcome Trust Centre is focused on research to improve the lives of patients with mitochondrial disease. This includes research to identify the genetic defect in patients with mitochondrial disease and his work also focuses understanding the molecular mechanisms underlying the neurological features in patients. With colleagues he is searching for new therapies for patients and actively involved in clinical studies evaluating potential therapies. He has been actively involved in work to prevent the transmission of mitochondrial DNA disease using an IVF technique called mitochondrial donation. Lead for the NHS Highly Specialised Services for Rare Mitochondrial Services for Adults and Children. Professor Turnbull developed this service provides optimum care for patients with mitochondrial disease throughout the UK with Centres in Newcastle, London and Oxford. This service was built on the back of clinical and basic research and the service reviews in excess of 800 patients per year. The service has developed care pathways and patient guidance that are used worldwide of the benefit of patients. Director MRC/BBSRC Centre for Ageing and Vitality. Professor Turnbull has a major
Advances in Pathobiology and Management of Pagets Disease of Bone presents an essential collection of up-to-date knowledge about the pathophysiology, genetics, and treatment of Pagets disease. It covers the comprehensive information related to clinical perspectives, epidemiology, genetics, environmental factors such as viral etiology, molecular abnormalities, complications such as osteosarcoma, and current and future treatment for Pagets disease. This book serves as a useful volume for basic scientists, graduate students, and practicing clinicians in understanding the pathobiology, etiology, and treatment of this disease. Discusses the current research of the nature of Pagets disease and its response to the latest treatments which are seminal in the management of this disease Helps users quickly assess the very latest details on the diverse scientific and clinical aspects of Pagets disease, as opposed to searching through multiple journal articles in the literature Presents work from featured leaders in Pagets disease around the globe Serves as a useful volume for basic scientists, graduate students, and practicing clinicians in understanding the pathobiology, etiology, and treatment of this disease
Document from the year 2016 in the subject Chemistry - Physical and Theoretical Chemistry, University of Duisburg-Essen, language: English, abstract: This is a book for all chemists who dont want to become theoretical chemists, but who want to understand user articles and presentations with theoretical concepts included and who want to use theoretical chemistry for there own projects. It gives an overview about: Hartree Fock Theory, Post-Hartree-Fock-Methods, Density-Functional-Theory, Solid-State-Physics, Force-Field Methods and Molecular Dynamics. Everything the chemist of the 21th century should know about Theoretical Chemistry, to be able to read articles with a satisfying yield of new informations, to be able to effectively talk to and work with theoretical chemists and to plan own calculations. The author offers an overview about Post-Hartree-Fock-Methods (Coupled Cluster (incl. Example for Application of Perturbation-Theory), Full CI, explicitly correlated methods) Density-Functional-Theory (Basic Equations, reason of lower computational cost, important Types of Functionals (LSD-Functionals, GGA-Functionals, Hybrid-Functionals)), Important points in searching the right method), Force-Field-methods (Basic Theory, Basic Equations, practical tips as tool in quantum-chemical Calculations), theoretical Solid-State Physics (differences to quantum chemical equations, special behavior of solid-state-systems, atomic groups with single-particle-behavior - like phonons, polarons, ...), the role of special techniques (Perturbation Theory, Group Theory) and shows connections of those techniques to molecular dynamics. For that he shows all necessary mathematics and derivations, when they are needed but just as deep as necessary. Not with the target to make the reader a theoretician. In front of the derivative part he commits his pictorial imagination of Hilbert-space, basis set, and quantum-chemical-calculations.
Sox2: Biology and Role in Development and Disease offers a thorough discussion of the important role of Sox2 in cellular and developmental processes, aimed at facilitating greater understanding of how Sox2 functions across different disciplines. The book discusses the basic biology of Sox2 to help establish the critical foundational knowledge necessary for deeper molecular and functional analysis. The book also provides insight into how the Sox2 transcription factor plays a key role in pluripotency induction, maintenance, and development. Helpful as a tool to organize new research projects, the book assists with preparing lessons, seminars, and thesis or research papers, thereby circumventing the need to spend hours searching through journal databases. A single source for the basic biology of Sox2, Sox2: Biology and Its Role in Development and Disease provides information on networks, gene regulation, and regulatory function in a number of cell types and tissues types. Discusses the important role of Sox2 in cellular and developmental processes Facilitates a greater understanding of how Sox2 functions across different disciplines Assists in identifying, circumventing and modifying the dynamics of Sox2 in cell types Provides greater understanding of the structure of Sox2 and its gene networks Identifies aspects of phenotypic spectrum uncovered following greater understanding of Sox2 during development
Vitamin,D:,Volume,2:,Health, Disease,and,Therapeutics, Fourth,Edition, ,authoritatively,covers,the,evidence,for,new,roles,for,vitamin,D,,ranging,from,cardiovascular,disease,,to,cancer,,diabetes,,inflammatory,bowel,disease,,multiple,sclerosis,and,renal,disease., , This,collection,represents,a,whos,who,of,vitamin,D,research,and,the,coverage,is,appropriately,broad,,drawing,in,internal,medicine,,orthopedics,,oncology,and,immunology.,Clinical,researchers,will,gain,a,strong,understanding,of,the,molecular,basis,for,a,particular,area,of,focus. Offers,a,comprehensive,reference,,ranging,from,basic,bone,biology,,to,biochemistry,,to,the,clinical,diagnostic,and,management,implications,of,vitamin,D Saves,researchers,and,clinicians,time,in,quickly,accessing,the,very,latest,details,on,the,diverse,scientific,and,clinical,aspects,of,Vitamin,D,,as,opposed,to,searching,through,thousands,of,journal,articles Chapter,authors,include,the,most,prominent,and,well-published,names,in,the,field Targets,chemistry,,metabolism,and,circulation,,mechanisms,of,action,,mineral,and,bone,homeostasis,and,vitamin,D,deficiency Presents,a,clinical,focus,on,disorders,,analogs,,cancer,,immunity,,inflammation,,disease,and,therapeutic,applications
This book is about the importance of water in determining the structure, stability and responsive behavior of biological membranes. Water confers to lipid membranes unique features in terms of surface and mechanical properties. The analysis of the hydration forces, plasticiser effects, controlled hydration, formation of microdomains of confined water suggests that water is an active constituent in a water-lipid system. The chapters describe water organization at the lipid membrane-water interphase, the water penetration, the long range water structure in the presence of lipid membranes by means of X-ray and neutron scattering, general polarization, fluorescent probes, ATR-FTIR and near infrared spectroscopies, piezo electric methods, computer simulation and surface thermodynamics. Permeation, percolation, osmotic stress, polarization, protrusion, sorption, hydrophobicity, density fluctuations are treated in detail in self-assembled bilayers. Studies in lipid monolayers show the correlation of surface pressure with water activity and its role in peptide and enzyme interactions. The book concludes with a discussion on anhydrobiosis and the effect of water replacement in microdomains and its consequence for cell function. New definitions of lipid/water interphases consider water not only as a structural-making solvent but as a mediator in signalling metabolic activity, modulating protein insertion and enzymatic activity, triggering oscillatory reactions and functioning of membrane bound receptors. Since these effects occur at the molecular level, membrane hydration appears fundamental to understand the behavior of nano systems and confined environments mimicking biological systems. These insights in structural, thermodynamical and mechanical water properties give a base for new paradigms in membrane structure and function for those interested in biophysics, physical chemistry, biology, bio and nano medicine, biochemistry, biotechnology and nano sciences searching for biotechnological inputs in human health, food industry, plant growing and energy conversion.
Get the quick answers you need on every aspect of clinical ophthalmology and apply them in your day-to-day practice . The latest edition of Ophthalmology by Drs. Yanoff and Duker presents practical, expert, concise guidance on nearly every ophthalmic condition and procedure, equipping you to efficiently overcome whatever clinical challenges you may face. Apply the latest advances in the diagnosis and treatment of ocular disease, including new drug therapies for retinal disorders; todays expanded uses of optical coherence tomography (OCT) and high-resolution imaging modalities; new corneal, cataract and refractive surgical approaches; and new developments in molecular biology and genetics, ocular surface disease, glaucoma testing, neuro-ophthalmology, uveitis, ocular tumors, and much more. Visualize how to proceed by viewing more than 2200 illustrations (1,900 in full color) depicting the complete range of clinical disorders, imaging methods, and surgical techniques. Hone and expand your surgical skills by watching 40 brand-new videos demonstrating key techniques in cornea, cataract, refractive, retina and glaucoma surgery. Spend less time searching thanks to a user-friendly visual format designed for quick, easy-in easy-out reference and an instant understanding on any topic.
This volume focuses on contributions from both the mathematics and life science community surrounding the concepts of time and dynamicity of nature, two significant elements which are often overlooked in modeling process to avoid exponential computations. The book is divided into three distinct parts: dynamics of genomes and genetic variation, dynamics of motifs, and dynamics of biological networks. Chapters included in dynamics of genomes and genetic variation analyze the molecular mechanisms and evolutionary processes that shape the structure and function of genomes and those that govern genome dynamics. The dynamics of motifs portion of the volume provides an overview of current methods for motif searching in DNA, RNA and proteins, a key process to discover emergent properties of cells, tissues, and organisms. The part devoted to the dynamics of biological networks covers networks aptly discusses networks in complex biological functions and activities that interpret processes in cells. Moreover, chapters in this section examine several mathematical models and algorithms available for integration, analysis, and characterization. Once life scientists began to produce experimental data at an unprecedented pace, it become clear that mathematical models were necessary to interpret data, to structure information with the aim to unveil biological mechanisms, discover results, and make predictions. The second annual Bringing Maths to Life workshop held in Naples, Italy October 2015, enabled a bi-directional flow of ideas from and international group of mathematicians and biologists. The venue allowed mathematicians to introduce novel algorithms, methods, and software that may be useful to model aspects of life science, and life scientists posed new challenges for mathematicians. Alessandra Rogato is researcher at Institute of Bioscience and BioResources of the Italian National Research Council (CNR). Her research interests have been progressively enriched by the different research experiences she had working in different research Institutes: at the Institute of Genetics and Biophysics Adriano Buzzati-Traverso (CNR) in Naples Italy during her PhD studies and, after at the Stazione Zoologica A. Dhorn of Naples in Italy for her post-doc; and in Paris, France, as young investigator at Laboratoire de Génomique des Microorganismes UMR 7238 CNRS-UPMC, and shorter working experiences at the Department of Genetics and Experimental Bioinformatics at University of Freiburg, Germany and at the Weizmann Institute of Science in Rehovor, Israel. Major objective of her research interests is to decipher the molecular secrets underlying the ecological success of living photosyntetic organisms (plants and marine microalgae) and their capacity for handling different adaptive solutions in order to succeed in a variable environment. In paricular her research interests is to fully exploit novel genetic tools and genomic information to identify the mechanisms controlling marine diatom growth and distribution in the marine environment. Valeria Zazzu - From 2013 until 2015, CNR Researcher at Institute of Genetics and Biophysics (IGB) ABT in Naples, Italy, involved in the project New markers identifying dementia: a multidisciplinary approach, aiming at cross-linking dementia with neurodegenerative processes.From 2011 until 2012, member of the leading scientific coordination team for the IT Future of Medicine initiative, focussed on personalised medicine, one of the EU FET flagship pilot projects launched by the European Commission, at the Max Planck Institute for Molecular Genetics, Berlin, Germany.In 2011 PhD degree in Molecular Biology, Humboldt University, Berlin, Germany. Thesis title The human G protein-coupled receptor GPR30: interaction partners and expression analysis in endothelial cells.From 2006 until 2011, with a Marie Curie PhD fellowship, PhD student in the laboratory of Prof. Ruiz Noppinger at the Center for Cardiovascular Research, Charité - Universitätsmedizin (Berlin, Germany).In 2004 Master of Science in Biology, University of Naples Federico II, Naples, Italy. Thesis title: Functional characterisation of a novel protein interacting with the onco-protein Bcl-XL. Mario Guarracino is researcher at High Performance Computing and Networking Institute of the Italian National Research Council. He received a PhD in Mathematics defending a thesis on projection techniques for parallel sparse linear algebra and an Ms in Applied